Duodenal gastrointestinal stromal tumors (GISTs) are uncommon and may be difficult to treat surgically when the tumors involve papilla of Vater. We describe a 70-year-old woman presenting with epigastric pain and syncope due to ulceration and bleeding from a duodenal GIST. Surgical resection of the tumor was abandoned because the tumor was too close to papilla of Vater. We performed an endoloop-and-let-go technique using a standard single-accessory channel endoscope and a detachable endoloop to reduce the tumor size and relieve the patient's symptoms. Follow-up of the patient for 4 years revealed no progression of the tumor or recurrence of bleeding. Although the risks of incomplete tumor reduction and recurrence may exist, this endolooping technique may be considered as a safe alternative treatment for patients with GIST not fit for complete surgical resection.