Effect of Neoadjuvant Chemoradiotherapy in a Patient with Advanced Gastric Cancer

術前輔助性化療對一位進行性胃癌病人的效用

林建華(Chien-Hua Lin) ； 吳鴻昇(Hurng-Sheng Wu) ； 俞志誠(Jyh-Cherng Yu) ； 詹德全(De-Chuan Chan)

《中華民國癌症醫學會雜誌》 25卷3期 (2009/06) Pp. 216-221

https://doi.org/10.6588/JCOS.2009.25.3.7

摘要

胃癌治療的目標是要能完全的將腫瘤及其相關的淋巴結全切除。術後的輔助性化療似乎並沒有改善太大的預後，而有幾篇文章顯示術前輔助性化療，可以降低腫瘤的期別並且改善將腫瘤徹底切除的比例，然而，並沒有很多的資料來針對胃癌以術前或術後輔助性化療的效果來做比較。我們報告一個42歲進行性胃癌的女性案例，她先接受以5-fluorouracil及cisplantin為主的化療，然後再進一步接受手術，腫瘤及其在主動脈旁轉移的淋巴結因為接受化療之後明顯的變小。術前的輔助性化療對這位病患似乎達到了“細胞減量”的作用。

關鍵字

術前輔助性化療 ； 胃癌 ； 化療 ； 順鉑 ； 5-FU

並列摘要

The goal of treating patients with gastric cancer is based on complete surgical resection of the tumor and its lymphatic drainage. Postoperative adjuvant chemotherapy shows no significant prognostic advantage. Several studies of preoperative adjuvant chemoradiotherapy have shown the benefits of downstaging and improving the ratio of R0 resection. However, there is no data concerning the comparison of preoperative with postoperative adjuvant chemoradiotherapy. We report a 42-year-old woman with advanced gastric adenocarcinoma who received 5-fluorouracil, leucovorin and cisplantin-based chemoradiotherapy followed by surgery. Remarkable tumor reduction was observed in the primary tumor and metastatic paraaortic lymph nodes. Neoadjuvant chemoradiotherapy for this patient was effective in achieving the goal of cytoreduction.

並列關鍵字

Neoadjuvant ； Gastric cancer ； Chemoradiotherapy ； Cisplatin ； 5-FU