This thesis based on the Pure Practice Chapter of Avatamsaka Sutra, where Zhishou (智首) Bodhisattva raised 110 questions on how to purify the body, speech and mind. Manjusri Bodhisattva answered these questions with a phrase ”Applying the skillful use of the mind”. He also demonstrated with 141 Great Vows in encountering countless conditions in life, training one's mind from experiences, avoid the unwholesome and cultivate the wholesome in order to prevent the mind from defaults. ”Everything comes from the mind” is a quote from Avatamsaka Sutra. In order to search deep into the question regarding life philosophizing in overcoming the negativities in life, and to advance a healthy body and mind, this thesis focused on how one should cultivate the transformation of mind, and apply the skillful use of mind into positive thoughts, and practice the turning and transformation of the mind only. Besides the introduction and the conclusion of the thesis, the rest of the thesis had divided into three parts. The first part is about the meaning of ”mind” among the eminent teachers of Huayen School and also its meaning in the Avatamsaka Sutra. The second part focused on the skillful use or the transformation of mind and positive thinking. The third part discussed about the life philosophizing of the turning and transformation of mind only.