The Antioxidant and Free Radical Scavenging Properties of Acteoside

邱文慧(Wei-Fei Chiou) ； 林麗純(Lie-Chwen Lin) ； 陳介甫(Chieh-Fu Chen)

《The Chinese Pharmaceutical Journal》 55卷5期 (2003/10) Pp. 347-353

https://doi.org/10.7019/CPJ.200310.0347

並列摘要

Oxidation of low-density lipoprotein(LDY) is implicated in the developinent of atherosclerosis and dietary antioxidants may provide a useful therapy for the prevention of LDL oxidation and atheroma development. The aim of these experiments was to investigate the antioxidant profile of acteoside, a phenylethanoid compound isolated horn Orobanche caerulescens in in vitro models. Acheoside (0.625, 1.25, and 5μM) suppressed both copper- and AAPH-mediated oxidation of LDL in a concentration dcpenddnt manner by lengthening the time for conjugated diene formation as well as decreasing the oxidation rate and peak diene formation and displayed more potent effects than resveratrol. The electrophoretic mobility shift evoked by copper-catalyzed increase of the migration rate of oxidized LDL on gels was also inhibited by acteoside, Furthermore acteoside decreased the absorption of DPPH and appeared to he the most efficient in comparison with the four reference compounds α-tocopherol, vitamin C, probucol, and resveratrol. Since the oxidative modification of LDL plays an important role in the genesis of atherosclerosis, acteoside may be helpful to reduce the risk of atherosclerosis, not only by protecting LDL from oxidative modification but also by its free radical scavenging properties.

並列關鍵字

Acteoside ； LDL ； DPPH ； Free radical scavenger