A 44-year-old female patient was admitted to the hospital because of intermittent high fever. Sepsis was diagnosed from a blood culture. Rheumatological profiles showed high anti-nuclear, anti-dsDNA and anticardiolipin antibody titers. During hospitalization, the patient complained of blurred vision and headache. MR imaging showed multiple infarcts. In spite of corticosteroid and antiplatelet treatment, she developed the second stoke and died nine months after admission. The strokes may have been caused by antiphospholipid antibody-related thrombosis. The association of stroke with such thrombosis is discussed in medical reviews.