中國腦血管病相關因素之研究

Study on Cerebrovascular Disease-Related Factors in China

何邦平(Bang-Ping He) ； 李東方(Dong-Fang Li) ； 趙德山(De-Shan Zhao)

《慈濟醫學雜誌》 10卷3期 (1998/09) Pp. 189-199

https://doi.org/10.6440/TZUCMJ.199809.0189

摘要

腦血管病是40歲以上中老年死亡、致殘的主要病因。為評價腦血管病的發病與有關危險因素的關係，本研究於1990年10月~1994年6月應用自行設計的定量評估腦血管病危險度的積分方法，在中國腦血管病發病率不同的25個地區40歲以上的62.5萬框架人群中篩選腦血管病高危險個體，並對腦血管病的相關因素進行分析。結果顯示：(1)、積分值與腦血管病的機率呈正相關；(2)、腦血管病的發病率與血壓、空腹血糖、胰島素、C-肕、載脂蛋白B等水平呈正相關，這與中國腦血管病發病率的區域性變化規律相一致；(3)、腦血管病高危險個體具有高血壓、高血糖、高胰島素、高C-肕、高載脂蛋白B、低血糖/胰島素比值、低血糖/C-肕比值、低載脂蛋白A-I、低載脂蛋白A-I/載脂蛋白B比值等特徵，這些結果均為胰島素抵抗的表現；(4)、血壓及血清膽固醇水平又分別與膳食Na/K、Zn/Cu、Ca/Mg比值及脂質分值(Keys分值)呈顯著關聯，提示採取全人群預防策略(維持正常體重、控制食鹽的攝入量、降低膳食中動約性脂肪的攝入量、不吸煙、不飲酒、控制血糖及高血壓防治等)，提倡健康的生活方式可以防止危險因素及發病率的繼續上升。

關鍵字

腦血管病 ； 發病率 ； 危險因素 ； 高危險個體

並列摘要

Cerebrovascular disease is a major cause of both death and disability in peo;le overe the age of 40 years. To assess the relationship between the incidence of cerebrovascular disease and risk factors, high-risk populations sus-ceptible to cerebrovascular disease were screened with self-designed scoring method for quantitatively evaluation the risk of cerebrovasctlar disease. A total of 625000 people over the age of 40 years in 25 areas in China with different incidence of cerebrovascular disease and related factors were analyzed from October 1990 through June 1994. We was found that (1) Scoring values positively correlated with probabilies of cerebrovascular disease. (2) The varying regional trends of the levels of the systolic and diastolic blood pressue., fasting blood sugar, insulin, C-peptide, and apolipoprotein B, were in positive correlation to regional cerebrovascular disease morbidity rates were the same as those of cerebrovascular disease morbidity rates in China. (3) High-risk individuals were characterized by insulin resistance which includes hypertension, higher C-peptide, hyperinsulinemia, obese, hyperglycemia, high apolipoprotein B, low blood sugar/insulin ratios, low blood sugar/C-peptide ratios, low apolipoprotein A-I and Low apolipoprotein A-I/apolipoprotein B ratios. (4) The evidence of significant associations between some dietary factors (Na/K,Zn/Cu,Ca/Mg,Keys score) and mean levels of systolic and diastolic blood pressure and serum cheolesterol suggested the possibility of stopping the increasing incidence of cerebrovascular diseases by adoption population strategy(attention should be paid to maintain normal body weight, control salt intake, decreas animal fat intake, quit smoking, quit drinking, control fasting blood sguar, prevention and control hypertension, et al) and promoting healthy lifestles.

並列關鍵字

cerebrovascular diseases ； incidence ； risk factors ； high-risk individuals