We diagnosed 13 cases of Kaposi’s sarcoma in eastern Taiwan between May 1993 and May 1998. The diagnosis was proved by histological examination in all cases. The patients included 11 men and 2 women, from 31 to 69 years old. Ten patients were Taiwan aborigines. Two male patients were infected with HIV (human immunodeficiency virus) and 11 patients were HIV negative. Six patients were immunosuppressed, including the 2 patients with HIV infection and 4 patients on long-term corticosteroid therapy for gouty arthritis or psoriasis. Our observations indicate that Kaposi’s sarcoma, especially the classic or immunosuppression-associated types, is not an uncommon malignancy in aborigines in eastern Taiwan. Further epidemiological study is needed to clarify the prevalence rate and ethnic relationship.