- 期刊
Molecular Approach to Antiretroviral Therapy for Human Immunodeficiency Virus Infection
並列摘要
Sixty million people were estimated to be infected with human immunodeficiency virus (HIV) at the end of 2001. HIV is the leading cause of death in sub-Saharan Africa, responsible for one in five deaths in this region. Currently 4,070 Taiwanese were infected with HIV and were registered (until September 1, 2002). At present there are 19 antiretroviral agents approved by Food and Drug Administrations (FDA). Antiretroviral regimens are complex, have serious toxicity, pose difficulty with compliance, and carry serious consequences from the development of viral resistance. Though adequate antiretroviral treatment could achieve maximal viral suppression, the way of eradication of virus is still under researched. Immune reconstitutions, therapeutic and/or preventive vaccines have been tried, and still ongoing. The knowledge of immunology and the rationales of therapies should to be updated periodically to catch up the rapid evolution of new information. In this article we introduce the molecular mechanisms of current available medications and reviewed the recent development of HIV management. Relationships between clinical treatment and immunological responses are also described.
延伸閱讀
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