- 期刊
Expression of Cyclin D1 and p16INK4 Gene Products in Human Ovarian Cancer
並列摘要
Several changes have been documented in epithelial ovarian cancer including altered production and response to peptide growth factors, activation of protooncogenes, and inactivation of tumor suppressor genes. It has been observed that alterations of cyclin D1 and cdk inhibitor p16INK4 induce the abnormal cell proliferation. In this study, we investigated whether overexpression of cyclin D1 and loss of expression of p16INK4 occur in epithelial ovarian cancer. Specimens of normal ovaries and ovarian tumors were obtained and snap frozen at the time of operation. All histological slides were reviewed to confirm the diagnosis and histological subtypes of human ovarian tumors. Immunohistochemical staining for cyclin D1 and p16INK4 was performed in freshly frozen samples of ovarian tumors. Specific staining for cyclin D1 was observed in 12(66.7%)of 18 ovarian cancers and 2(40%)of 5 borderline malignant tumors. Loss of expression of p16INK4 protein was found in 10(55.6%)of 18 ovarian cancer and 2(40%)of 5 borderline tumors. According to the results of our study on limited number of ovarian tumor tissue specimens, there is a correlation between the over-expression of cyclin D1 and loss of expression of p16INK4 in human epithelial ovarian cancer, implicating that both of them are important cell cycle regulators relevant to tumorigenesis of human epithelial ovarian cancer.
延伸閱讀
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