In this study, we investigated the association of the genetic polymorphisms of CYPlAl, CYP2E1, GSTMl and GSTTl with the risk of esophageal cancer in Taiwan. We recruited 105 cases of esophageal squamous cell carcinoma and 266 persons of healthy controls during 1996-1999. The genotypes of the xenobiotic metabolizing enzymes were determined by PCR or PCR-RFLP. There was no significant difference in distribution of these genotypes between the patients and controls. However, among the cigarette smokers, GSTTl null genotype was found to associate a higher risk of esophageal cancer, after adjustment with other environmental confounders (OR: 2.44;95% CI:1.17-5.08). Our results revealed that the GSTTl genetic polymorphism might interact with cigarette smoke to modulate the risk of esophageal cancer in Taiwan.
為了持續優化網站功能與使用者體驗,本網站將Cookies分析技術用於網站營運、分析和個人化服務之目的。
若您繼續瀏覽本網站,即表示您同意本網站使用Cookies。