Papillary Thyroid Carcinoma with Anaplastic Transformation: A Case Report

甲狀腺乳突癌變性爲甲狀腺分化不良癌：病例報告

黃如君(Ju-Chun Huang) ； 黃純真(Shun-Chen Huang) ； 周逢復(Feng-Fu Chou) ； 王佩文(Pei-Wen Wang)

《內科學誌》 20卷2期 (2009/04) Pp. 167-170

https://doi.org/10.6314/JIMT.2009.20(2).09

摘要

甲狀腺分化不良癌是極惡性的癌症，預後極差。大約兩成的病人之前曾有甲狀腺分化癌的病史。另一方面，大約兩成至三成的病人併有甲狀腺分化癌。在此，我們提出一位甲狀腺乳突癌變性爲甲狀腺分化不良癌的病例。病人表現爲右頸腫瘤合併肺部轉移並於診斷後半年內死亡。多重基因的變異和甲狀腺分化癌轉變成甲狀腺分化不良癌相關。傳統治療方法對治療甲狀腺分化不良癌效果差。針對腫瘤致癌過程的治療方式是值得進一步研究的課題。

並列摘要

Anaplastic thyroid carcinoma (ATC) is one of the most aggressive malignancies with poor prognosis. Approximately 20 % of patients with ATC have a history of differentiated thyroid carcinoma, and 20 to 30 % have a coexisting differentiated thyroid carcinoma. We report a case of papillary thyroid carcinoma (PTC) with anaplastic transformation after follow-up for 17 years. Patient presented with an ulcerative mass over the previous surgical wound. Further examination revealed lung metastasis. Patient expired within half a year after ATC was diagnosed. Conventional therapies provide little aid in treating ATC. Multiple molecular abnormalities have been disclosed with the progression of normal follicular thyroid cells to ATC. This should provoke the development of innovative strategies beyond the conventional methods to overcome the lethal disease.

並列關鍵字

Papillary thyroid carcinoma ； Anaplastic thyroid carcinoma ； Anaplastic transformation