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以干擾素治療C型肝炎引發之精神病及停用後的譫妄

Interferon Induced Psychotic Disorder and Withdrawal Delirium during the Treatment of Chronic Hepatitis C

摘要


慢性病毒性肝炎的積極治療仍以干擾素(interferon)為主流,但使用後有許多神經精神系統的併發症。本文提出一例慢性C型肝炎病患於接受干擾素注射治療後不同時間點出現的精神病及譫妄(delirium)症狀,經入院治療使用低劑量抗精神病藥物後症狀緩解,藉此討論干擾素造成之精神症狀及其相關之機轉。

並列摘要


Interferons are the main therapy for chronic viral hepatitis. However, many neuropsychiatric adverse reactions have been reported. We report here that a patient with chronic hepatitis C developed psychotic symptoms and delirium at different time after receiving interferon injection. The above symptoms subsided after low dose anti-psychotic treatment. We also discuss the possible mechanisms of interferon-induced psychiatric symptoms.

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