- 期刊
- OpenAccess
Familial Polyposis Coli and Colonic Carcinoma-A Family Report
家族性息肉症與大腸癌－家族病例報告
摘要
「家族性息肉症」係於chromosome 5靠近bands 5q^21-q^22處異常的一種顯性遺傳疾病。鋇鹽灌腸檢查可見在結腸，特別是直乙狀結腸，散佈著無數2-5(上標 mm)大小的息肉。 今有一62歲男性因腹痛、腹瀉、體重減輕而求診，被診斷為大腸息肉症。七位子女接受雙對比劑鋇鹽灌腸及大腸纖維鏡檢查，證實其中三位亦患有息肉症，且一位巳惡化成癌，充份說明了家族性息肉症的遺傳性以及它與結腸癌之間的密切關係。
關鍵字
無資料並列摘要
Familial polyposis coli (FPC) is inherited as a non-sex linked autosomal dominant trait with a possibility of 50% inheritance. It is manifested as a defect on the chromosome 5, most likely near bands 5q^21-q^221. It's characteristic is that on the colon, especially the rectosigmoid colon, more than 100 polyps can be found. Double contrast barium enema study^2 may show numerous polyps cover the entire colon. A 62-year-old male with vague abdominal pain, diarrhea and body weight loss was examined in July 1988. The diagnosis was colonic polyposis. 3 of his 7 children revealed FPC with 1 case already showing malignant changes. This confirms the intimate relationship between FPC and colon cancer.
延伸閱讀
- Liu, C. C., Chen, T. M., & Jeng, Y. C. (2015). 自費大腸鏡檢群體中的結直腸腫瘤性息肉與偶發性增生型息肉的盛行率及相關因素. 童綜合醫學雜誌, 9(2), 91-99. https://www.airitilibrary.com/Article/Detail?DocID=20713592-201512-201512310005-201512310005-91-99
- Chiu, K. W., Chien, C. S. C., Chen, L., & Fan, H. A. (1992). 大腸息肉症腺腫與癌症之演變：一例報告. 中華民國消化系醫學會雜誌, 9(2), 173-177. https://doi.org/10.6557/GJTa.199206_9(2).0011
- Kuo, H. T., Lin, C. Y., Chen, J. J., Tsai, S. L., Sheu, M. J., Jung, Y. C., & Tang, H. C. (2003). 同發性大腸腺癌與胃粘膜相關淋巴組織瘤：一病例報告. 臺灣消化醫學雜誌, 20(2), 160-167. https://doi.org/10.6557/GJT.200306_20(2).0006
- Chiang, J. M., Chiang, S. F., Hsieh, P. S., Yeh, C. Y., You, J. F., Huang, H. Y., 蔡文司, Chen, J. S., 游耀東, & Tang, R. (2018). 比較不同家族史對於結直腸癌病人之臨床病理特徵，異時性結直腸癌的風險及術後存活之影響. 中華民國大腸直腸外科醫學會雜誌, 29(1), 45-55. https://doi.org/10.6312/SCRSTW.2018.29(1).10624
- Wu, M. C., Tsao, T. Y., & Liao, C. W. (2022). 大腸戒環狀細胞腺癌：個案報告. 內科學誌, 33(4), 308-311. https://doi.org/10.6314/JIMT.202208_33(4).06