Findings by magnetic resonance imaging (MRI) and computed tomography (CT)in the brains of three glue sniffers with chronic toluene encephalopathy are described. Abnormalities included (1) diffuse cerebral, cerebellar and brain stem atrophy on CT and MR images; (2) on MRI, increased signal intensity in the centrum semiovale; and (3) high signal intensity of the posterior limb of the internal capsule; and (4) decreased signal intensity of both thalami on T2WI. Chronic toluene encephalopathy in glue sniffers is not uncommon. However, it has not previously been reported in Taiwan. The CT and MR images were compared, and a review of the literature is included.