鎵(Ga)金屬是一種過渡元素,在製造如砷化鎵等高頻半導體產業上,使用量逐漸增加。本研究的目的乃在探討鎵對鯉魚的急性毒性效應、血清中生化因子及血液中紅血球的型態變化。經急性毒性試驗得知,暴露於不同鎵溶液的鯉魚,其96小時的半致死濃度(96-h LC50)為19.78(18.49-21.16) mg/L,鯉魚在3個不同鎵濃度(2.0、4.0、8.0 mg/L)中暴露28日後,由測定血清生化因子(血糖,glucose; 血中尿素氮,blood urea nitrogen;肌酐酸,creatinine;膽固醇,cholesterol;三酸甘油脂,triglyceride)的結果得知、處理組的生化因子平均值與對照組之間有顯著的差異。此外,鯉魚紅血球型態上的改變,可作為在暴露於鎵金屬溶液中,導致鯉魚呼吸受到干擾的另一個指標。我們的研究結果顯示:2.0mg Ga/L為鯉魚的生物安全濃度;血清中生化因子及紅血球的型態改變,可考慮作為評估鯉魚受鎵金屬毒性效應的臨床診斷工具。
Gallium (Ga) is one of the intermetallic elements that are increasingly being used in making high-speed semiconductors such as gallium arsenide. The purposes of this study were to investigate its acute toxicity and its effects on serum biochemical variables as well as erythrocyte morphological changes in the bloodstream of common carp (Cyprinus carpio). The 96-h median lethal concentration (LC50) determined in acute tests was 19.78 (18.49-21.16) mg/L. Based on this datum, common carp were exposed to different gallium concentrations (2.0, 4.0, and 8.0 mg/L) for 28 d in laboratory chronic tests. It was found that the means of the measured serum biochemistry parameters (including glucose, blood urea nitrogen, creatinine, cholesterol, and triglyceride) of these exposed groups significantly differed from those of the untreated group. Deformation of erythrocytes suggests that disturbance of respiration occur as an additional indicator of Ga exposure. Our results show that 2.0 mg/L could be proposed as a biologically safe concentration. Changes in both serum biochemical and erythrocyte morphological parameters can be considered promising clinical diagnostic tools for assessing the toxic effects of gallium compounds on common carp.
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