Altered glycosylation is found in all cancer cells, compared with normal cells. Sialic acid might be one of the most important molecules, since it is located on the terminal end of various kinds of oligosaccharides. Although this glycosylation of protein contributes to the half-life of circulating proteins, recent evidence shows it also contributes to the interaction between the cells. We found that overexpression of α 2,6-linked glycosylation and suppression of α 2,3-linked glycosylation in cervical cancer cells compared with normal cervix; however, when metastases of the cervical cancers occur, continuous overexpression of α 2,6-linked glycosylation but reverse overexpression of α 2,3-linked glycosylation is found in the cervical cancers, supposing that dynamic alternation of glycosylation might be important for tumor invasion and metastases.
為了持續優化網站功能與使用者體驗,本網站將Cookies分析技術用於網站營運、分析和個人化服務之目的。
若您繼續瀏覽本網站,即表示您同意本網站使用Cookies。