摘要
鼻硬結病屬於一種慢性肉芽腫性傳染病，多侵犯呼吸道黏膜並造成上呼吸道阻塞的相關症狀，甚至進一步侵犯腦部。本院於2008年4月經歷一例鼻硬結病例。患者是1名28歲男性，主訴鼻塞及張口呼吸約半年，鼻腔檢查發現雙側下鼻甲與鼻中膈粘黏以及鼻中膈彎曲，經安排鼻中隔成形術同時切開粘黏處，病理切片發現典型含有細菌的米庫利茲細胞(Mikulicz cells)，Wharthin-Starry及PAS染色鏡檢發現許多棒狀的細菌，證實診斷爲鼻硬結病。術後持續於門診追蹤並給予口服四環黴素8週療程，追蹤至今，發現下鼻甲沾黏有復發情形，但無惡化或擴散至鼻腔以外現象，此病在台灣相當罕見，特提出此例並回顧相關文獻。
並列摘要
Rhinoscleroma is a rare disease of chronic progressive granulomatous infection that most frequently affects the upper airway and results in the symptoms and signs of upper airway obstruction. This disease has been widely reported from Africa, central and south America, South Central and East Europe, the Middle East, India, China and southeast Asia. We reported a case of rhinoscleroma in Taiwan. The patient was a 28-yr-old man, who suffered from nasal obstruction and open mouth breathing for 6 months. The diagnosis of rhinoscleroma was confirmed by the presence of Mikulicz cells in nasal biopsy. With Wharthin-Starry silver and periodic acid-Schiff stains, many rod-shape bacilli were found in the Mikulicz cells. The antibiotic therapy was started with tetracycline when the diagnosis was confirmed and was carried on for 2 months. During a 6-month follow-up period, local recurrence was noted but there was no evidence of invasion in areas other than the nasal cavity.
延伸閱讀
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