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Validation of the Taiwanese Version of the 22-Item Sino-nasal Outcome Test

台灣版SNOT-22量表的認證

摘要


BACKGROUND: A measure of health related quality of life is important in clinical outcome research for sinonasal diseases. The purpose of this study was to translate the 22-item Sino-nasal Outcome Test into Chinese and assess its validity.METHODS: From August, 2011 to April, 2012, volunteers without sinonasal diseases and patients with allergic rhinitis or rhinosinusitis were enrolled to test the Taiwanese version Sino-nasal Outcome Test-22 (TWSNOT-22) in the study hospital. Two weeks afterwards, 20 patients with allergic rhinitis took the test again if they did not receive treatment and their symptoms did not change. Patients with allergic rhinitis or rhinosinusitis also were assessed with a visual analog scale (VAS) of nasal symptoms and daily impact of nasal symptoms. Fours weeks afterwards, these participants were invited to undergo the same assessment and have the transition of disease status scores graded.RESULTS: Twenty healthy volunteers, 56 patients with allergic rhinitis and 52 patients with rhinosinusitis were enrolled. The median TWSNOT-22 scores of healthy volunteers, patients with allergic rhinitis and those with rhinosinutis were 7.5 (0-28), 33.5 (3-83) and 39 (5-94), respectively. The TWSONT-22 demonstrated good internal consistency (Cronbach's α = 0.937) and test-retest reliability (p < 0.001). There were significant differences in the scores between healthy volunteers and patients with allergic rhinitis as well as those with rhinosinutis (both p <0.001). The scores of TWSNOT-22 were significantly correlated to those of VAS of symptoms and daily impact (both p <0.001). In addition, TWSNOT demonstrated good responsiveness to the transition of disease status.CONCLUSIONS: The TWSNOT-22 is reliable and valid for measuring healthrelated quality of life in Taiwanese patients with rhinitis and rhinosinusitis.

並列摘要


BACKGROUND: A measure of health related quality of life is important in clinical outcome research for sinonasal diseases. The purpose of this study was to translate the 22-item Sino-nasal Outcome Test into Chinese and assess its validity.METHODS: From August, 2011 to April, 2012, volunteers without sinonasal diseases and patients with allergic rhinitis or rhinosinusitis were enrolled to test the Taiwanese version Sino-nasal Outcome Test-22 (TWSNOT-22) in the study hospital. Two weeks afterwards, 20 patients with allergic rhinitis took the test again if they did not receive treatment and their symptoms did not change. Patients with allergic rhinitis or rhinosinusitis also were assessed with a visual analog scale (VAS) of nasal symptoms and daily impact of nasal symptoms. Fours weeks afterwards, these participants were invited to undergo the same assessment and have the transition of disease status scores graded.RESULTS: Twenty healthy volunteers, 56 patients with allergic rhinitis and 52 patients with rhinosinusitis were enrolled. The median TWSNOT-22 scores of healthy volunteers, patients with allergic rhinitis and those with rhinosinutis were 7.5 (0-28), 33.5 (3-83) and 39 (5-94), respectively. The TWSONT-22 demonstrated good internal consistency (Cronbach's α = 0.937) and test-retest reliability (p < 0.001). There were significant differences in the scores between healthy volunteers and patients with allergic rhinitis as well as those with rhinosinutis (both p <0.001). The scores of TWSNOT-22 were significantly correlated to those of VAS of symptoms and daily impact (both p <0.001). In addition, TWSNOT demonstrated good responsiveness to the transition of disease status.CONCLUSIONS: The TWSNOT-22 is reliable and valid for measuring healthrelated quality of life in Taiwanese patients with rhinitis and rhinosinusitis.

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