Arytenoid Plasmacytoma

杓狀軟骨漿細胞瘤

林維宏(Wei-Hung Lin) ； 莊文郁(Wen-Yu Chuang) ； 黃祥富(Shiang-Fu Huang)

《台灣耳鼻喉頭頸外科雜誌》 48卷3期 (2013/09) Pp. 247-252

https://doi.org/10.6286/2013.48.3.247

摘要

孤立性骨髓外漿細胞瘤占頭頸部癌症不到百分之一，喉部的孤立性骨髓外漿細胞瘤不常見，位於喉部杓狀軟骨更是罕見，迄今只見於少數的病例報告。一80歲男性開始主訴為非特異性喉嚨痛1週。喉內視鏡發現位於喉部杓狀軟骨的潰瘍性腫塊，病理切片和免疫組織化學染色證實是k抗體輕鏈漿細胞瘤。經排除全身性漿細胞病變後，病患接受放射線治療後腫瘤消失並控制良好。對於喉部黏膜下或潰瘍性腫塊的診斷，建議深部切片以避免偽陰性，細胞型態特性與免疫組織化學染色可以確診漿細胞瘤。基於截然不同的治療方式和預後，漿細胞瘤必須區分為孤立性骨髓外漿細胞瘤和全身性漿細胞病變，孤立性骨髓外漿細胞瘤以放射線治療為主，然而少數情況下可以接受手術，治療後，必須長期追蹤。

關鍵字

漿細胞瘤 ； 喉 ； 杓狀軟骨

並列摘要

Solitary extramedullary plasmacytoma (SEP) accounts for less than 1% of malignancies in the head and neck region. Solitary extramedullary plasmacytoma of the larynx is uncommon, and in the arytenoid it is extremely rare with only a few cases reported to date.We reported the case of an 80-year-old male who presented with nonspecific sore throat for one week. An office laryngoscopy revealed right arytenoid ulcerative tumor extending to aryepiglottic fold. Histopathology and immunohistochemical staining confirmed the diagnosis of Kappa light chain plasmacytoma. Systemic evaluation excluded the systemic plasma cell dyscrasias. The patient received radiation therapy (XRT), and the tumor was eradicated.For the diagnosis of submucosal or ulcerated mass of the larynx, deep biopsy is required to reduce false-negative results. For distinct therapy and prognosis, SEP should be separated from other systemic plasma cell dyscrasias. XRT remains the mainstay of treatment, however surgery may be preferred in some circumstances. After therapy, long-term follow-up is necessary.

並列關鍵字

plasmacytoma ； larynx ； arytenoid