In January 2016, Taiwan Centers for Disease Control confirmed the first case oflaboratory-confirmed Zika virus infection imported into Taiwan. The patient,24-year-old male residing in northeastern Thailand, presented fever and headache forone day and was detected with a high body temperature at the quarantine station uponhis arrival in Taiwan Taoyuan International Airport. His fellow travelers had sore throatsbut were tested negative for Zika virus and dengue virus. The public health authoritiesimmediately implemented vector control measures after laboratory confirmation. Zikavirus is primarily transmitted to humans by infected mosquitos. The vectors, Aedesaegypti and A. albopitus, are present in Taiwan, and early diagnosis and timelynotification of public health authorities is the key to quickly implement vector controlmeasurements. This report highlights the need for increasing physician and publicawareness, education, enhance surveillance, and management of microcephaly and otherneurological complications that might be related to Zika virus infection.