Cancer induced bone pain is common and challenging to treatment. Prostate cancer has a high tendency for metastasis to bone. Malignant invasion of the skeleton, metastatic bone destruction leads to increased morbidity and impaired quality of life as a result of pain, fractures and other skeletal related events .Although there are a variety of drugs, but there are still limits its clinical. How to relieve the patient's pain due to bone metastasis is important. Clinical management of bone pain due to bone metastasis involving use of a multimodal treatment approach comprising analgesic agents (opioids, NSAIDs), radiotherapy, radioisotopes, cancer chemotherapy agents and bisphosphonates. The treatment should be individualized according to the patient's clinical condition, life expectancy, and quality of life.
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