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Effectiveness of High-dose Intravenous Vitamin C on Acute Herpetic Pain

高劑量靜脈注射維生素C對急性皰疹痛的療效

摘要


Intravenous high-dose vitamin C is a potentially useful therapy for acute herpetic pain, but its minimum effective dose and target serum concentration have not been established. It was reported that intravenous vitamin C in a total dose of 60-75 g was effective in mitigating acute herpetic pain, while that of 15 g was not. We report two cases whose acute herpetic pain was resistant to traditional treatment but effectively relieved by intravenous high-dose vitamin C (total doses 40 and 30 g, respectively); final serum levels of vitamin C were 23.1 and 20.3 μg/ml, respectively. These findings support the notion that the effect of vitamin C on acute herpetic pain is dose-dependent, and a serum vitamin C level greater than 20 μg/ml may be needed to relieve acute herpetic pain.

並列摘要


靜脈注射高劑量維生素C可望成為急性皰疹痛的有效療法,但目前尚未確立其最低有效劑量及目標血清濃度。曾有研究指出靜脈注射總劑量60至75克的維生素C可有效緩解急性皰疹痛,但15克則無效。在此報告兩個急性皰疹痛的病例,以傳統方式治療無效,但靜脈注射高劑量維生素C(總劑量各為40及30克)可有效減輕疼痛;維生素C的最終血清濃度各為23.1及20.3 μg/ml。由以上發現可見維生素C對於急性皰疹痛的療效與劑量有關,而且維生素C的血清濃度可能需大於20 μg/ml才足以緩解急性皰疹痛。

並列關鍵字

維生素C 帶狀皰疹 急性皰疹痛

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