NPR1蛋白在植物「誘導性系統抗病反應」中最重要的調控因子,此蛋白不僅可以正向促進由水楊酸(salicylic acid, SA)調控的「系統性後天抗病(systemic acquired resistance, (SAR)」反應,也可以負向抑制由茉莉香酸(jasmonic acid)調控的「誘導性系統抗病(induced systemic resistance ISR)」反應。在SAR啓動之初,被SA活化的NPR1蛋白可以與一些還原態的TGA轉錄因子結合,來共同誘導並累積「病程相關蛋白(pathogenesis-related proteins, PR proteins)」。此外,NPR1蛋白可能與一些轉錄因子;例如:WRKY70(此蛋白包含高度保留的WRKYGQK胺基酸序列)等蛋白結合,藉此調控SAR與ISR兩種反應。
The Arabidopsis NPR1 protein is the most important regulator for plant systemic induced responses. It not only promotes the salicylic acid (SA) mediated systemic acquired resistance (SAR) but also is involved in crosstalk inhibition of jasmonic acid (JA)-mediated induced systemic resistance (ISR). After the initiation of SAR, activation of NPR1 and its binding to some TGA transcription factors under the reducing conditions could subsequently induce the accumulation of pathogenesis related proteins. In addition to NPR1 and TGA, other transcription factor such as WRKY70 protein is also found to be involved in SA-mediated defense and crosstalk between SA- and JA- signaling pathways.
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