Most of the current high-rise buildings use raft foundation as their main foundation system, and the modulus of subgrade reaction (Ks) is considered as one of the essential design parameters. Basically, modulus of subgrade reaction is not just a soil parameter, it is affected by the structural stiffness as well. This paper lists various approaches for the selection of Ks; an example is provided for comparison purpose. The effects of diaphragm wall and structural stiffness is addressed, and the authors also recommend a set of Ks values for reference. For critical structural design, it is suggested that a sensitivity study on Ks be always carried out.