內分泌干擾物質對人體健康之可能影響

Potential Effects of Endocrine Disruptors on Human Health

李美慧(MEI-HUI LI)

《台灣公共衛生雜誌》 21卷5期 (2002/10) Pp. 305-320

https://doi.org/10.6288/TJPH2002-21-05-01

摘要

在過去十多年來，實驗室的研究及野生動物的調查發現許多人工合成及自然的物質都具有干擾內分泌系統的作用，也使得內分泌干擾物質對人類與野生動物之影響成為目前受到大眾關切的公共衛生及環境問題。目前從人類流行病學研究資料，可發現睪丸癌及乳癌之發生率都有增加的現象。另外，男性的精子數、尿道下裂、隱睪症、女孩性早熟、神經內分泌及行為方面等的問題雖然沒有確切證據顯示有增加的趨勢，但是也有一些研究指出內分泌干擾物質可能與人類生殖及兒童發育方面之問題有關。本文將先介紹內分泌干擾物質的定義，再討論常見內分泌干擾物質作用方式及種類。最後針對內分泌干擾物質所可能造成之人類健康影響做一完整介紹。

關鍵字

內分泌干擾物質,人體健康,生殖影響,天生缺陷,癌症

並列摘要

Over the past decade, evidence from laboratory studies and wildlife observations has indicated endocrine disruption effects of many synthetic or natural chemicals. Indeed, the effects of endocrine disruptors in public health and the environment have caused a growing concern among the public. In humans, there is some evidence increases in incidences of testicular and breast. cancers, and concern has also been expressed regarding sperm count, crytorchidism, hypospadias, precocious puberty, neuroendocrine development, and behavioral effects. This review will introduce the definition, mechanisms of action and types of endocrine disruptors, as well as the potential impacts on human health mediated by endocrine disruptors.

並列關鍵字

Endocrine disruptor,Human health,Reproductive effect,Birth defect,Cancer

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