Creutzfeldt-Jakob disease (CJD) is not common in the medical environment occupational injuries unless diagnosed, medical environment more unusual this case, easy for clinical workers neglect protection. This case is a CJD cases, family members to assist with routine follow admission Creutzfeldt-Jakob disease cases, though it is a routine check, but not to know when it will morbidity cases, especially with clinical cases occur also cited a clinical workers from panic strain is likely to cause poor clinical workers and their families patient antagonism purpose of this cas is to by the unit management perspective, to take responsibility for good management, whereby cases and literature evidence, on cooperation and communication with the medical team, the medical team for Creutzfeldt-Jakob disease can further understanding of front-line workers to provide a safer working environment, to avoid occupational injury level employees.