Familial Aggregation of Lung Cancer in Taiwan: A Report of Three Family Cases and Review of the Literature

肺癌的家族聚集性：三個家族的病例報告及文獻回顧

林志鴻(Chih-Hung Lin) ； 陳育民(Yuh-Min Chen) ； 蔡俊明(Chun-Ming Tsai) ； 彭瑞鵬(Ruery-Perng Perng)

《胸腔醫學》 18卷2期 (2003/04) Pp. 163-168

摘要

雖然肺癌的家族聚集性在美國自一九六三年就有報告，在臺灣卻罕有文獻記載。近幾年來因診斷技術及公共衛生進步，肺癌的家族聚集性被發現有增加的趨勢。因此我們收集在近二年來診斷的三個家族共六個病例，來討論他們的共同環境危險因子及可能的基因感受性。在我們的個案中，生活方式及及環境的危險因子，特別演重要的角色。而遺傳的成份，可能只有次要的地位。今後如果要早期發現肺癌及降低其死亡率，我們建議應藉由分子生物學，特別是基因及蛋白質表現的研究，分辨出肺癌的高危險群，提供他們早期的教育，規則的篩檢及醫療追蹤。

關鍵字

家族性聚集 ； 肺癌

並列摘要

Although familial aggregations of lung cancer have been reported since 1963 in the United States, it has been rarely documented in Taiwan. With the improvement in diagnostic techniques and public health, familial aggregations have been found in increasing frequency in recent years. Thus, we studied six cases in three families, diagnosed in the most recent two years, to discuss the roles of shared environmental risk factors and possible genetic susceptibility in these families. In these cases, shared lifestyles, environmental risks, and inherent components may possibly have contributed to the familial aggregations. For the early detection of lung cancer and a decrease of in the mortality rate, it is suggested that high-risk individuals be identified with the aid of molecular biology, especially genomic or proteonomic studies, so that early education, regular screening, and close medical follow up can be performed with these high-risk patients.

並列關鍵字

familial aggregation ； lung cancer