Oseltamivir-Induced Delirium in an Elderly Patient: Report of a Case and Literature Review

Oseltamivir引起之譫妄：病例報告及文獻回顧

鄭景元(Ching-Yuan Cheng) ； 江俊松(Jiunn-Song Jiang)

《胸腔醫學》 29卷4期 (2014/08) Pp. 252-256

摘要

Oseltamivir為預防與治療流感病毒感染的神經胺酸酶抑制劑，此藥物最常見的副作用有噁心、嘔吐、腹痛等胃腸道症狀。老年人服藥後產生譫妄的副作用則少有文獻報導。我們提出了一個80歲的男性病例，此患者過去有慢性阻塞性肺病、第2型糖尿病以及冠狀動脈疾病經冠狀動脈繞道手術、高血壓、高血脂、攝護腺肥大以及類風濕性關節炎的病史。此次因為發燒、乾咳和肌肉痠痛兩天而前來求診，流感快篩結果顯示B型流感陽性。在服用oseltamivir治療第四天開始出現譫妄，症狀在停藥後逐漸消失。此案例報告提醒臨床醫療人員在老人使用oseltamivir應注意譫妄此副作用的發生。

關鍵字

流行性感冒 ； 譫妄

並列摘要

Oseltamivir is an influenza virus neuraminidase inhibitor. It is commonly prescribed for the prevention and treatment of influenza virus infection. The most common side effects are gastrointestinal symptoms such as nausea, vomiting and abdominal pain. Delirium rarely has been reported in the elderly. We present the case of an 80-year-old man who developed delirium after taking oseltamivir. He had a past history of chronic obstructive pulmonary disease, type 2 diabetes mellitus, triple-vessel coronary artery disease that underwent coronary artery bypass graft surgery, hypertension, dyslipidemia, benign prostate hypertrophy and rheumatoid arthritis. He was admitted due to fever, dry cough and myalgia for 2 days. Influenza B rapid test was positive. Delirium developed 4 days after he took oseltamivir and gradually subsided after ceasing it. This case report should remind medical staff of possibility of inducing delirium in the elderly with oseltamivir use.

並列關鍵字

oseltamivir ； influenza ； delirium