- 期刊
Primary Pulmonary Extranodal Natural Killer/T-cell Lymphoma: A Case Report
原發性肺部結外自然殺手型T細胞淋巴瘤：個案報告與文獻探討
摘要
一般原發於肺部淋巴瘤在臨床上常常與典型社區型肺炎難以區分，病人經抗生素治療過一段時間後症狀和影像學上皆不會改善，而常見的原發性淋巴瘤是B細胞淋巴瘤，而結外自然殺手型T細胞淋巴瘤 通常好發於皮膚、腸胃道、睪丸、唾液腺、胰臟、軟組織、中樞神經系統和骨髓，而原發在肺部的個案相當稀少。我們的案例報告是一個47歲女性持續乾咳長達6個月，起初被誤判為肺結核，治療長達五個月未見改善，胸部X光及電腦斷層顯示右下肺葉有一個開洞，經電腦斷層指引切片發現為結外自然殺手型T細胞淋巴瘤，接受新的化學治療後，病人病情改善。
並列摘要
Primary pulmonary lymphoma (PPL) is rare, and is usually of a low-grade B-cell lymphoma type. Most cases are reported as extranodal non-Hodgkin’s lymphoma. Natural killer (NK)/T-cell lymphoma primarily involving the lung is extremely rare. Herein, we report the case of a 47-year-old female patient who initially presented with dry cough for 6 months. A diagnosis of tuberculosis was made at a regional hospital and she was treated with antituberculosis medication for 5 months. However, a chest radiograph showed new formation of a cavity with increasing thickness of the wall, indicating no improvement with the treatment. After admission to our hospital, a computed tomography-guided biopsy confirmed the diagnosis of NK/T-cell lymphoma. She underwent appropriate chemotherapy, after which her condition and chest radiography both showed improvement, and eventually, complete remission. We also review the literature and discuss the use of the DeVIC chemotherapy regimen as an alternative to CHOP for the treatment of NK/T-cell lymphoma of the lung.
延伸閱讀
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