Radiotherapy of Nasopharyngeal Carcinoma in the Young Age Group: a Review From Mackay Memorial Hospital

年青病人鼻咽癌之放射線治療一馬偕醫院之經驗

高仲瑜(Chung-Yu Kao) ； 賴允亮(Yuen-Liang Lai) ； 鍾昌宏(Chang-Hung Chung) ； 葉啓源(Chi-Yuan Yeh) ； 吳孟浩(Meng-Hao Wu) ； 張國茟(Kuo-Hwa Chang)

《放射治療與腫瘤學》 1卷1期 (1994/03) Pp. 17-26

https://doi.org/10.6316/TRO/199401(1)17

摘要

鼻咽癌通常好發於中年人，較少發生在小孩及青年之病人。本院對於37例小於30歲之年青鼻咽癌病人作回溯性分析，其中有25例男性，12例女性臨床分期用1988AJC之分期系統，11例(30%)屬於T4，25例(68%)屬於N2以上之晚期淋巴轉移，有2例(6%)於診斷時即有遠端轉移，所有病人都接受放射線治療，部分病人並且接受化學治療作為輔助性治療或遠端轉移之全身治療，全體病人5年之存活率及無病存活率分別為56%及48%。本院之經驗顯示，放射治療對於局部病灶之控制相當有效，而潛在性之遠端轉移是治療失敗及導致病人死亡之主要原因；因此，尋找有效控制遠端轉移之輔助性治療對於治療結果之提昇是必要的。

關鍵字

鼻咽癌 ； 年青病人 ； 放射線治療

並列摘要

Nasopharyngeal carcinoma (NPC) most often occurs in middle age; it is rarely found in children and young adults. The clinical findings and treatment results in 37 patients with NPC under 30 years of age were retrospectively analyzed. There were 25 males and 12 females. The anatomical extent of disease was described using 1988 AJC classification. Eleven patients (30%) presented with T4lesions, 25 patients (68%) with advanced neck lymphadenopathy (N2+N3), and two patients (6%) with distant metastases. All pateints received radiotherapy, some patients also received chemotherapy as an adjuvant treatment or salvage when distant metastases developed. The overall 5-year survival and disease free survival rates were 56% and 48%, respectively. Radiotherapy is effective in controlling local disease. Occult distant metastases, increasing with more advanced N-stage disease, is the major cause of death and the chief obstacle to successful treatment. The search for an effective adjuvant treatment for systemic control is urgently needed to improve the therapeutic result.

並列關鍵字

NPC ； young patients ； radiotherapy