Hyperfractionation for Head & Neck Cancer: a Preliminary Report From Chang-Hua Christian Hospital

頭頸部癌症每日射兩次之放射治療

劉幕台(Mu-Tai Liu)

《放射治療與腫瘤學》 1卷1期 (1994/03) Pp. 33-37

https://doi.org/10.6316/TRO/199401(1)33

摘要

每日照射兩次之理論基礎是在晚期反應組織的忍受範圍內每次給予較小的劑量，而提高總劑量的放射治療。其他的理論基礎是經由再分配記現象，使細胞放射敏感性增加，及對氧效應的依存度降低。在 1992 年 7 月至 1993 年 6 月間，有 19 例頭頸部癌症患者接受每日兩次照射治療。腫瘤原發部位及頸部每次照劑量為 115cGy。兩次照射相隔約六小時。使用 6MV 的 X 射線，每周治療五天。在 6.5 周間分 64-66 次，給予總劑量 7360 cGy-7590cGy . 18 位患者腫瘤完全消退，一位 N3 的患者，頸部腫瘤部份消退。經手術切除後，病理報告証實已無癌細胞存在。六位病人發生二度黏膜炎，其餘 13 位發生三度黏膜炎，其中兩位需中斷抬療一周。通常黏膜炎在照射結束後 1-2 周即消退。

關鍵字

每日多次放射治療

並列摘要

The rationale of hyperfraetionation is that the use of smaller dose per fraction allows higher total dose to be administered within the tolerance of late-responding tissues, Other rationales for hyper- fractionation are radiosensitization through redistribution and lesser dependence on oxygen effect. Between July 1992 and June 1993, 19 patients of previously untreated head and neck cancer received treatment with twice-a-day irradiation. A dose of 115 cGy was administered to the primary site and neck at each treatment session. The interfraction interval was usually 6 hours. Treatments were administered 5 days a week using 6 MV x-ray. The total dose was 7360 cGy/64 - 7590 cGy/66 fractions over 6.5 weeks. Complete response achieved in 18 patients. One patient with large neck node (N3) achieved partial response. The residual node was excised, pathological examination showed no evidence of cancer. Six patients developed Grade 2 mucositis, the remaining 13 deve- loped Grade 3 mucositis, two of them necessitated a treatment interruption of one week. Usually the mucositis subsided 1 - 2 weeks after completion of irradiation.

並列關鍵字

Hyperfractionation