Postoperative Radiotherapy for Malignant Parotid Gland Tumors

惡性腮腺腫瘤之手術後放射線治療

王麗鈴(Lily Wang) ； 詹建勝(Jian-Sheng Jan) ； 林進清(Jih-Ching Lin) ； 曾顯群(Hsien-Chun Tseng) ； 翁忠恕(Yih-Chyang Weng) ； 高忠恕(Chung-Shuh Kao)

《放射治療與腫瘤學》 4卷2期 (1997/06) Pp. 109-115

https://doi.org/10.6316/TRO/199704(2)109

摘要

Purpose: To evaluate the treatment results and analyze the prognostic factors of postoperative radiotherapy for malignant parotid gland tumors.
Materials and Methods: From January 1984 to December 1993, 42 patients with malignant parotid gland tumors received a complete course of radiotherapy at Taichung Veterans General Hospital. Twenty-eight of the 42 patients were treated with postoperative radiotherapy. There were 12 males and 16 females, between 15 and 78 years old (median: 46). The numbers of the patients in stage I to IV were 8, 6, 3, and 11, respectively. The types of cancer included mucoepidermoid carcinoma,8; adenocarcinoma,6; epidermoid caroinoma,3; adenoid cystic carcinoma,3; malignant mixed tumor,2; adenosquamous cell caroinoma,2; undifferentiated caroinoma,2; acinic cell carcinoma,1; and lymphoepithelioma-like carcinoma, 1. Most patients were treated with Go-60 using unilateral wedge pair fields and an electron beam local boost. The dose of radiotherapy was 57 to 72 Gy (median: 60 Gy).
Results: The patients were followed up till January 1997. The 5-year and 10-year overall survival rates were 78% and 65%, respectively. The 5-year local control rate was 89%. Three patients developed local recurrences at 3-12 months, 6 patients developed distant metastases at 3-69 months, and 2 had combined local recurrences and distant metastases. Most failure occurred in the first year after surgery. Five-year survival rates for stage Ito IV were 100%, 83%, 100%, and 55%, respectively. Lymph node involvement, stage, and histology were the significant prognostic factors (P＜0.05).
Conclusions: Postoperative radiotherapy was effective in eradicating microscopic residual tumors and yielded a good local control rate. Lymph node involvement, stage, and histology were the significant prognostic factors. Lymph node involvement, stage IV tumors, and adenocarcinoma indicated a relatively poor prognosis.

關鍵字

惡性腮腺腫瘤 ； 手術後放射線治療

並列摘要

Purpose: To evaluate the treatment results and analyze the prognostic factors of postoperative radiotherapy for malignant parotid gland tumors.
Materials and Methods: From January 1984 to December 1993, 42 patients with malignant parotid gland tumors received a complete course of radiotherapy at Taichung Veterans General Hospital. Twenty-eight of the 42 patients were treated with postoperative radiotherapy. There were 12 males and 16 females, between 15 and 78 years old (median: 46). The numbers of the patients in stage I to IV were 8, 6, 3, and 11, respectively. The types of cancer included mucoepidermoid carcinoma,8; adenocarcinoma,6; epidermoid caroinoma,3; adenoid cystic carcinoma,3; malignant mixed tumor,2; adenosquamous cell caroinoma,2; undifferentiated caroinoma,2; acinic cell carcinoma,1; and lymphoepithelioma-like carcinoma, 1. Most patients were treated with Go-60 using unilateral wedge pair fields and an electron beam local boost. The dose of radiotherapy was 57 to 72 Gy (median: 60 Gy).
Results: The patients were followed up till January 1997. The 5-year and 10-year overall survival rates were 78% and 65%, respectively. The 5-year local control rate was 89%. Three patients developed local recurrences at 3-12 months, 6 patients developed distant metastases at 3-69 months, and 2 had combined local recurrences and distant metastases. Most failure occurred in the first year after surgery. Five-year survival rates for stage Ito IV were 100%, 83%, 100%, and 55%, respectively. Lymph node involvement, stage, and histology were the significant prognostic factors (P＜0.05).
Conclusions: Postoperative radiotherapy was effective in eradicating microscopic residual tumors and yielded a good local control rate. Lymph node involvement, stage, and histology were the significant prognostic factors. Lymph node involvement, stage IV tumors, and adenocarcinoma indicated a relatively poor prognosis.

並列關鍵字

Malignant parotid gland tumors ； Postoperative radiotherapy