Tumors originated in retroperitoneum are rare and usually the primary treatment is surgery. We report a case of double tumors, retroperitoneal lymphoma and ovarian teratoma with unusual presentation. The patient presented with low back soreness, lower leg edema and numbness, abdominal fullness. She was treated by the gynecologist, orthopedics and oncologist. She was treated with CHOP regimen chemotherapy combined with radiation 3060 cGy. Rapid tumor lysis was complicated with abscess formation, fistula and necrotizing fasciitis.