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評估肝癌患者放射治療前後營養狀態與其生活品質之探討

Evaluate the Nutritional Status and Quality of Life for the Patients with Hepatocellular Carcinoma Treated by Radiotherapy

摘要


Purpose: The aims of this study are assessing the nutritional status and quality of life (QoL) in the patients with hepatocellular carcinoma treated by radiotherapy, and discussing the impacts of radiotherapy and nutritional status on QoL. Materails and Methods: From August 2007 to April 2009, one hundred and fifty hepatocellular carcinoma patients treated by radiotherapy at a teaching hospital in central Taiwan were enrolled in this study. Nutritional status and QoL of the patients were assessed by means of the Mini-Nutrition Assessment (MNA) and European Organization for Research and Treatment of Cancer Quality of Life Core-3D (EORTC QLQ-C30) at three different time points: before treatment, end of treatment, and 1 month after treatment. Results: Forty-two percent patients had the problem of nutritional status before radiotherapy. There was no significant changes in nutritional status of the patient s who received radiotheray (Friedman X^2 = 2.06, p = 0.358). The nutritional status correlated with global health status, all five functioning scales and the most of symptom scales /item at all of the different time points. Using generalized estimating equation, global health status (p < 0.01), global functioning status (p < 0.05), the most severe symptoms included fatigue (p < 0.05), financial difficulty (p < 0.001 ), and pain ( p < 0.01) were significantly improved after radiotherapy. The nutritional status o f the patients were strong relationship with global health status (p < 0.001), global functioning status (p < 0.001), insomnia (p < 0.01), fatigue (p < 0.001), financial difficulty (p < 0.001), loss of appetite (p < 0.001) and pain (p < 0.01). Conclusion: Although the level o f nutritional status of the patients is not effectively increase in a short period, it would be worth to note that the QoL and the most of the major symptoms are significantly improved after the patient s received radiotherapy. Considering, the nutritional status of the patients will directly influence their QoL and the major symptoms. The patients with hepatocellular carcinoma should have to establish nutritional assessment and arrange early nutritional intervention before radiotherapy to get more nutritional support, and in turn to improve the QoL.

並列摘要


Purpose: The aims of this study are assessing the nutritional status and quality of life (QoL) in the patients with hepatocellular carcinoma treated by radiotherapy, and discussing the impacts of radiotherapy and nutritional status on QoL. Materails and Methods: From August 2007 to April 2009, one hundred and fifty hepatocellular carcinoma patients treated by radiotherapy at a teaching hospital in central Taiwan were enrolled in this study. Nutritional status and QoL of the patients were assessed by means of the Mini-Nutrition Assessment (MNA) and European Organization for Research and Treatment of Cancer Quality of Life Core-3D (EORTC QLQ-C30) at three different time points: before treatment, end of treatment, and 1 month after treatment. Results: Forty-two percent patients had the problem of nutritional status before radiotherapy. There was no significant changes in nutritional status of the patient s who received radiotheray (Friedman X^2 = 2.06, p = 0.358). The nutritional status correlated with global health status, all five functioning scales and the most of symptom scales /item at all of the different time points. Using generalized estimating equation, global health status (p < 0.01), global functioning status (p < 0.05), the most severe symptoms included fatigue (p < 0.05), financial difficulty (p < 0.001 ), and pain ( p < 0.01) were significantly improved after radiotherapy. The nutritional status o f the patients were strong relationship with global health status (p < 0.001), global functioning status (p < 0.001), insomnia (p < 0.01), fatigue (p < 0.001), financial difficulty (p < 0.001), loss of appetite (p < 0.001) and pain (p < 0.01). Conclusion: Although the level o f nutritional status of the patients is not effectively increase in a short period, it would be worth to note that the QoL and the most of the major symptoms are significantly improved after the patient s received radiotherapy. Considering, the nutritional status of the patients will directly influence their QoL and the major symptoms. The patients with hepatocellular carcinoma should have to establish nutritional assessment and arrange early nutritional intervention before radiotherapy to get more nutritional support, and in turn to improve the QoL.

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