Long-Term Outcome of Radiotherapy for Mucoepidermoid Carcinoma of the Head and Neck Region

目的：分析術後或直接接受放射線治療的頭頸部黏液上皮樣癌病人之長期治療效果及預後因子。材料與方法：從1984年6月到2009年5月，有37位之前未接受過治療，於術後或直接接受放射線治療至少50 Gy的頭頸部黏液上皮樣癌病人被納入這個研究。這個研究分析臨床及病理因子及存活率的關聯性。結果：5年整體存活率及5年無疾病存活率分別為85.5%及83.2%。單變項分析顯示性別（P=0.0005）、年紀（P=0.0008）、手術切緣（P=0.0031）、治療方式（P=0.0045）、原發腫瘤部位（P=0.0307）、及細胞學形態（P=0.0328）對於整體存活率有顯著影響。其中，治療方式（P=0.0014），手術切緣（P=0.0086）及性別（P=0.0175）也是無疾病存活率的重要因子。結論：單變項分析顯示，對於整體存活率及無疾病存活率而言，女性性別，乾淨的手術切緣及治療方式為手術加上放射線治療皆是較好的預後因子。而老年人，非腮腺腫瘤，及細胞學高惡性度腫瘤則有較差的整體存活率。

關鍵字

黏液上皮樣癌；放射線治療；預後因子

並列摘要

Purpose: To analyze the long-term treatment outcome and various prognostic factors in patients with mucoepidermoid carcinoma (MEC) arising from the head and neck region treated by radiotherapy with or without surgery.Materials and Methods: Thirty-seven patients with previously untreated MEC in the head and neck region who received at least 50 Gy of radiotherapy with or without precedent surgery from June 1984 to May 2009 were enrolled in this study. The relationship between clinical and pathologic characteristics and survival rate was investigatedResults: The 5-year overall survival (OS) and disease-free survival (DFS) rates were 85.5% and 83.2% respectively. Univariate analysis of OS demonstrated that the parameters which significantly affected survival were the gender (P=0.0005), age (P=0.0008), surgical margin (P=0.0031), treatment modality (P=0.0045), primary tumor site (P=0.0307), and histological grade (P=0.0328). The treatment modality (P=0.0014), surgical margin (P=0.0086), and gender (P=0.0175) were predictive factors of DFSConclusion: In univariate analysis, female gender, free surgical margins, and treatment by surgery plus radiotherapy were favorable prognostic factors in predicting both OS and DFS. Older age, non-parotid origin, and high grade tumor indicated worse OS.

並列關鍵字

Mucoepidermoid carcinoma ； Radiotherapy ； Prognostic factor

國際替代計量

Long-Term Outcome of Radiotherapy for Mucoepidermoid Carcinoma of the Head and Neck Region

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