單次口服辣椒素酯類物質無法減緩後續運動產生的疲勞

Acute oral capsinoids supplementation could not attenuate exercise induced fatigue in human studys

曹榮鑣(Jung-Piao Taso) ； 廖淑芬(Su-Fen Liao) ； 張嘉珍(Chia-Chen Chang) ； 林峰樟(Fong-Chang Lin) ； 程一雄(I-Shiung Cheng)

《體育學報》 52卷1期 (2019/03) Pp. 17-28

https://doi.org/10.3966/102472972019035201002

摘要

緒論：研究指出天然的辣椒素酯類物質（capsinoids, CSN）增加人體的能量消耗與脂肪氧化作用。當運動的能量來源偏向脂肪利用，有助於延緩疲勞與降低肝醣的分解，並促進運動表現。因此，本研究欲探討運動前攝取辣椒素酯類物質是否有利後續運動期間的脂肪氧化作用、延遲肌肉肝醣耗竭與運動疲勞的產生。方法：十名健康男性受試者（年齡：20.6 ± 0.3歲；身高：171.3 ± 2.4公分；體重：67.0 ± 3.4 kg ; BMI : 21.1 ± 0.6 kg/m^2 ; VO_2 max : 46.4 ± 2.4 ml/kg/min）分別完成安慰劑（placebo）試驗或辣椒素酯類物質（CSN），試驗兩種試驗至少間隔七天。受試者在試驗當天先食用輕熱量早餐，接著口服30 mg的辣椒素酯類物質或安慰劑膠囊後，在原地腳踏車上進行單次70分鐘的肌肉肝醣耗竭運動。在餐前、運動前與運動期間每20分鐘進行採血；運動期間全程採集氣體間接分析能量代謝；肌肉樣本在運動前、後進行採樣。結果：CSN試驗在運動期間第40與60分之甘油與非酯化脂肪酸濃度低於placebo（p ＜ .05）；CSN試驗的血氨與尿素濃度在運動期間第40、60分與運動結束明顯低於placebo（p ＜ .05）；CSN試驗的肌酸激酶在第60分與運動結束的濃度顯著較低（p ＜ .05）。兩種試驗在運動後的肌肉肝醣濃度顯著低於運動前（p ＜ .05）。CSN試驗沒有改變肌肉肝醣、血糖與乳酸等濃度，顯示單次補充CSN不會降低運動誘發的疲勞。結論：人體在運動前補充辣椒素酯類物質不會改變運動期間的脂肪氧化作用、延遲肌肉肝醣耗竭與運動疲勞的產生。

關鍵字

辣椒素酯類物質 ； 運動疲勞 ； 肌肉肝醣

並列摘要

Introduction: In previous study, a capsinoids intake would enhance the energy expenditure and fat oxidation in humans. If a capsinoids (CSN) can stimulate fat oxidation and spare glycogen stores following exercise resulting in delaying exercise-induced fatigue. The purpose of the study was to investigate the effect of acute oral CNS supplementation on fat oxidation, muscle glycogen and fatigue during exercise. Methods: Ten healthy subjects (age 20.6 ± 0.3 years; height 171.3 ± 2.4 cm; weight 67.0 ± 3.4 kg; BMI 21.1 ± 0.6 kg/m^2; VO_2 max 46.4 ± 2.4 ml/kg/min) completed a crossover study design with CNS and placebo trials and performed a single bout of cycling exercise challenge with glycogen depletion protocol for 70 minutes, separated a 7-d washout period. All subjects consumed 30 mg CSN or placebo with light breakfast before exercise challenge. Blood samples were measured before meal and during exercise. Expired gas samples were collected during exercise. Simultaneously, muscle biopsy samples were obtained from vastus lateralis before and immediately after exercise. Results: Plasma glycerol and non-esterified fatty acid, at 40 and 60 min during exercise were significantly lower after CSN consumption compared to placebo (p ＜ .05). Plasma ammonia and urea at 40th, 60th and the end of the exercise in the CSN trial were elevated compared with placebo (p ＜ .05). Lower response in creatine kinase at 60 min during exercise and immediately after exercise was found after CSN supplementation (p ＜ .05). Muscle glycogen content after exercise was reduced significantly in both CSN and placebo trials (p ＜ .05). No effect was found in this study after acute oral CSN supplementation on attenuating exercise-induced fatigue, based on no significant difference responses in muscle glycogen, blood glucose and lactate. Conclusion: Oral CSN supplementation could not change lipolysis during exercise, delay muscle glycogen depletion and attenuate subsequence exercise-induced fatigue.

並列關鍵字

capsinoids ； exercise-induced fatigue ； muscle glycogen

參考文獻

Bernard, B. K., Tsubuku, S., Kayahara, T., Maeda, K., Hamada, M., Nakamura, T., ... Mihara, R. (2008). Studies of the toxicological potential of capsinoids: X. Safety assessment and pharmacokinetics of capsinoids in healthy male volunteers after a single oral ingestion of CH-19 sweet extract. International Journal of Toxicology, 27(3), 137-147. doi: 10.1080/10915810802514476

Bloomer, R. J., Canale, R. E., Shastri, S., & Suvarnapathki, S. (2010). Effect of oral intake of capsaicinoid beadlets on catecholamine secretion and blood markers of lipolysis in healthy adults: A randomized, placebo controlled, double-blind, cross-over study. Lipids in Health and Disease, 9, 72. doi: 10.1186/1476-511X-9-72

De Matteis R., Lucertini F., Guescini M., Polidori E., Zeppa S., Stocchi V., ... Cuppini R. (2013). Exercise as a new physiological stimulus for brown adipose tissue activity. Nutrition, Metabolism and Cardiovascular Diseases, 23(6), 582-590. doi: 10.1016/j.numecd.2018.12.008

Galgani, J. E., Ryan, D. H., & Ravussin, E. (2010). Effect of capsinoids on energy metabolism in human subjects. British Journal of Nutrition, 103(1), 38-42. doi: 10.1017/S0007114509991358

Hargreaves, M. (2015). Exercise, muscle, and CHO metabolism. Scandinavian Journal of Medicine and Science in Sports, 25(4), 29-33. doi: 10.1111/sms.12607