The research studies the influence of brand equity, perceived value, relationship quality and perceived risk on customer loyalty when consumers purchase non-prescription drugs. This study investigates 503 consumers and the results indicate that brand equity has a most significant total effect on customer loyalty through Structural Equation Modeling (SEM). The next factor affecting customer loyalty is perceived value. Besides, relationship quality will affect customer loyalty through perceived risk. The study shows that it's necessary to adopt advertisement tactics to enhance brand awareness, brand image and diminish consumers perceived risk to improve customer loyalty. This study attempts to find out what consumers purchasing non-prescription drugs want and provides the sellers of non-prescription with some suggestions to make effective strategies.