不同去乙醯化度幾丁聚醣包覆精油微膠囊之製備及其緩釋性之探討

Preparation and Sustained Release Properties of Various Deacetylated Chitosan Microcapsules Containing Volatile Essential Oil

謝明孝(M. S. Hsieh) ； 陳忠益(C. Y. Chen) ； 謝文權(W. C Hsieh) ； 張志鵬(C. P. Chang)

《華岡紡織期刊》 14卷2期 (2007/06) Pp. 189-193

https://doi.org/10.29984/JHGT.200706.0010

摘要

本研究以蝦殼為原料經酸鹼處理復製備成幾丁質，再經高溫熱鹼處理製備不同去乙醯化度之幾丁聚醣當作微膠囊之殼材。將這些幾丁聚醣溶於2%酯酸水溶液中形成幾丁聚醣膠體，再以液中硬化法製成包覆揮發性精油的微膠囊，探討不同去乙醯化度幾丁聚醣之流變性與形成膠囊的可能性以及微膠囊中精油的緩釋行為。幾丁聚醣膠體經黏度測試後發現去乙醯化度達到88%以上，即使再經過延長熱鹼處理時間也無法大幅提升去乙醯化度，但是其膠體黏度卻有顯著下降之趨勢。以檸檬油為芯材，使用去乙醯化度為77%、82%、88%之幾丁聚醣作為殼材包覆之，比較原油與包覆後的制放曲線，發現包覆後的制放率呈線性圖形，且精油制放時間可較未經膠囊包覆之精油延長一倍，達到良好的緩釋效果。

關鍵字

去乙醯化度 ； 幾丁聚醣 ； 微膠囊 ； 揮發性精油 ； 制放

並列摘要

In this study, chitosan microcapsules containing volatile essential oil were prepared with various deacetylated chitosan wall materials by Orifice Method. The relation of deacetylated degree and viscosity of chitosan; the formation conditions of chitosan microcapsules and sustained release effect of volatile essential oil were investigated. The results indicated that the viscosity of chitosan was decreased with increasing the deacetylated degree of chitosan. The chitosan microcapsule can be obtained at the conditions of deacetylated degree 45%-90% of chitosan. The sustained release effect of volatile essential oil was improved over 100% by microencapsulated with chitosan wall membrane.

並列關鍵字

deacetylation ； chitosan ； microsphere ； volatile oil ； controlled release