The main purpose of this research was to investigate the feasibility of microwave irradiation for disinfecting paper-based artifacts. The following results were obtained: 3-5 min of microwave irradiation are a sufficient biocidal dosage to fungal strains. There were no apparent brightness or color changes for filter paper after 3-5 min of microwave irradiation, whereas a decrease in breaking length, folding, and degree of polymerization of the paper occurred gradually. The effect of microwave treatment on paper artifacts needs further investigation.