動物實驗模型於牙周組織再生之運用：文獻回顧

Usages of Variant Animal Models in Periodontal Regeneration: A Literature Review

黃國光(Kuo-Kuang Huang) ； 江正陽(Cheng-Yang Chiang) ； 沈一慶(E-Chin Shen) ； 謝耀東(Yao-Dung Hsieh) ； 傅鍔(Earl Fu)

《中華民國牙周病醫學會雜誌》 8卷2期 (2003/06) Pp. 153-168

摘要

牙周病專科醫師長久致力於研究促使因牙周病而導致破壞的牙周支持組織再生之工作，至今已有甚多文獻報告在測試臨床上使用各類新的藥物或生物材料在牙周組織再生方面之安全性與效果如何，然而以臨床檢測方式來得知牙周組織再生或修復的量是比較不可信的數據，唯有透過組織切片來證實；然而人體標本獲得困難使得動物實驗仍在牙周組織再生方面的研究領域上扮演著相當重要的角色，因此選擇一種能與人體解剖構造及牙周病進行過程類似的實驗動物模型是相當重要。本文回顧過去一些動物實驗文獻並加以整理與分類以供大家參考。

關鍵字

牙周病 ； 組織再生 ； 動物實驗模型

並列摘要

For many decades, periodontists have been intensely interested in regeneration tooth-supporting tissue destroyed by periodontal diseases. A lot of studies are performed to test pharmacologic agents, devices and biologicals which are intended to alter normal wound healing of periodontal flap procedures so as to result in regeneration. The major problem with clinical outcome measures is that they are unreliable in distinguishing between repair and regeneration. Controlled histological studies in humans are difficult because they require the retrieval of tissue blocks containing the teeth and their surrounding tissues, and for this reason these studies have largely been done in animal models. It is important to choose a laboratory animal model that has similar characteristics of human anatomy and periodontal diseases. This article reviews several animal models currently used.

並列關鍵字

periodontal disease ； regeneration ； animal models