This article is a case report of a woman who suffers from chronic periodontitis. Before periodontal treatment, she had 5 to 10 mm deep probing at almost every tooth. She received periodontal initial phase therapy、flap surgery and guided tissue regeneration. After 6 months, her full mouth probing depth were almost under 4 mm. Initial 80% bleeding on probing improved to 4%. 82% teeth had more than 3 mm attachment gain. Multiple intrabony defects were treated with DFDBA, membrane with DFDBA or open curettage alone, They all got apparent attachment gain increased bone level proved by radiography.