There is an increasing awareness that sex and gender differences may affect both health and disease. This is not only related to procreation or disorders of sex-specific organs, but there is also a range of variations in terms of the functioning of the male and female bodies, as well as variation in social behavior between the sexes. Regardless of epidemiological studies targeting periodontal diseases, which have generally shown that periodontal destruction is more prevalent among males than among females, the chance of treating women periodontal patients has never decreased. Women live longer and to access dental care differently, and seem to react to health promotion in a more positive manner. This article explores gender differences in terms of peridontal disease, certain systemic diseases with periodontal manifestations that are more prevalent in women and sex hormone related periodontal problems in women.