We report a case of acute cholestasis and renal failure due to sepsis after coronary bypass surgery. Progressively deteriorating hyperbilirubinemia (up to 31.6mg/dL) developed accompanied by multifocal seizures, two weeks after the onset of sepsis. A total of three sessions of plasma perfusion with a bilirubin-adsorption column removed 46% of the total serum bilirubin and helped control the seizures. Selective bilirubin adsorption therapy may be beneficial for removing serum bilirubin in patients with postoperative jaundice.