Background: Pre-medical intensive care (MICU) training is crucial for ICU-naïve residents, but there is still huge gap between awareness and clinical performance by means of didactic lecture in the classroom. Objectives: The purpose of this study aimed to combine flipped classroom (FC) and simulation-based education (SBE) to facilitate secondyear residents (R2) in pre-MICU training. Methods: A well-trained third-year resident (R3) (control mode) and thirteen R2 who did not practice in the MICU were included as participants. Each participant read the teaching material and online instruction before the FC and manipulated the SBE scenarios. The pre-curriculum written test score and the SBE results were compared as manifestation of a "match mismatch highlight (MMH)." Post-curriculum feedback questionnaire was provided for self-evaluation. Results: As a result, the residents achieved relatively higher scores in the written test than in the simulation (80.3 ± 9.4 vs. 68.7 ± 4.2), which confirmed the mismatch gap in awareness and performance. Compared to R3, the R2 fell short in the five scenarios, especially in first aid teamwork, invasive procedure, and mechanical ventilator. The training workshop not only earned their satisfaction toward FC and SBE, but also enhanced participants' ability in MICU (Likert scales, from 2.53 to 3.15, p<0.05) and alleviated MICU difficulties (Likert scales, from 4.38 to 4, p<0.05). Conclusion: The integrated FC and SBE workshop associated with MMH analysis may serve as an innovate methodology for pre-MICU training.