Quetiapine-associated Tardive Dyskinesia

Quetiapine相關之遲發性運動不能

陳興剛(Hsing-Kang Chen) ； 葉啟斌(Chin-Bin Yeh) ； 林為文(Wei-Wen Lin)

《台灣精神醫學》 22卷1期 (2008/03) Pp. 74-78

https://doi.org/10.29478/TJP.200803.0009

摘要

目的：本文將討論一雙極性疾患男性個案，使用quetiapine治療後出現遲發性運動不能情形。病例報告：一51歲男性雙極性第一型疾患患者，之前曾服用clothiapine, risperidone，及zotepine且出現巴金森氏症症狀。將藥物由zotepine轉換為quetiapine每天400毫克後症狀在一週內改善。服用quetiapine 5個月後開始出現反覆不由自主地吸氣、扮鬼臉等動作；停用quetiapine後上述症狀明顯改善。之後個案至另一家醫院追蹤，再次開立quetiapine每天400毫克，上述症狀惡化，至本院住院評估，停藥後三週症狀明顯改善並出院。結論：quetiapine的使用與遲發性運動不能的發生可能相關，臨床上仍需留意。

關鍵字

抗精神病藥物 ； 遲發性運動不能 ； quetiapine ； 雙極性疾患

並列摘要

Objective: To report a case of tardive dyskinesia in a patient treated with quetiapine. Case report: A 51-year-old male had been treated with antipsychitics for 3 years, including clothiapine 40mg/d, risperidone 2-4mg/d, and zotepine 150mg/d, individually. He was switched from zotepine to quetiapine 400mg/d due to parkinsonism, which subsided 1 week after the change, however, the TD symptoms were subsequently noted 5 months later. These symptoms improved significantly after discontinuation of the quetiapine, but worsened after the quetiapine (400mg/d) was again prescribed during admission to another hospital. In the beginning of his latest hospitalization, all medications were discontinued because the patient's manic symptoms had been in full remission for at least 10 months. He was discharged 3 weeks after hospitalization with significant improvement of the TD symptoms. Conclusion: This single case report suggests that quetiapine might be associated with occurrence of TD symptoms although the frequency is presumably much rarer than that of conventional antipsychotics.

並列關鍵字

antipsychotics ； tardive dyskinesia ； quetiapine ； bipolar disorder

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