Prevalence of HIV, Hepatitis B, Hepatitis C in Patients Participating in the Methadone Maintenance Treatment in Central Taiwan

中台灣美沙冬替代療法個案人類免疫缺陷病毒感染、B型肝炎感染及C型肝炎感染盛行率

許文郁(Wen-Yu Hsu) ； 劉瑞婷(Jui-Ting Liu) ； 張庭綱(Ting-Gang Chang) ； 廖以誠(Yi-Cheng Liao) ； 邱南英(Nan-Ying Chiu)

《台灣精神醫學》 27卷1期 (2013/03) Pp. 33-40

並列摘要

Objective: Transmission of human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) are important issues in heroin addicts. In this study, we investigated the prevalences of HIV, HBV, and HCV infections and analyzed the associations between relative factors in heroin addicts, who were enrolled in the methadone maintenance treatment (MMT), in central Taiwan from January 2007 to February 2011. Method: This is a retrospect study. We reviewed the medical records of subjects enrolling in the MMT in Changhua Christian Hospital, a medical center, and Lu tung Branch of Changhua Christian Hospital, a psychiatric subspecialty hospital, in central Taiwan. Results: We enrolled 1,149 subjects, including 1,012 male subjects (88.1%) and 137 female subjects (11.9%). We found that 232 subjects (20.2%) had HIV, 546 subjects (47.5%) HBsAb-positive, and 335 subjects (29.2%) hepatitis B-positive status. A total of 982 subjects (85.5%) was found to have hepatitis C infection, including 757 non-HIV subjects (82.6%) and 225 HIV carriers (97.0%). We found that there was significant relationship between intravenous injection and HCV-positive status (p ＜ 0.001). Subjects with HCV-positive status had significantly higher GOT (p ＜ 0.05), higher GPT (p ＜ 0.001), younger age of heroin first time using (p ＜ 0.001), more abstinence heroin times (p ＜ 0.001), and longer heroin using duration (p ＜ 0.001). Male (p ＜ 0.05), intravenous injection user (p ＜ 0.001), lower education level (p ＜ 0.05), unemployment status (p ＜ 0.05), and HCV infection were related with HIV-positive status. Subjects with HIV positive status also had significant higher mean of γ-GT (p ＜ 0.05), older age (p ＜ 0.05), times of heroin abstinence (p ＜ 0.05), and heroin using duration (p ＜ 0.001). Conclusion: This population should be closely followed for their infection condition, and receive effective intervention more early. Further basic or clinical studies for co-infection of HCV and HIV are needed.

並列關鍵字

human immunodefi ciency virus (HIV) ； hepatitis B virus (HBV) ； hepatitis C virus (HCV) ； methadone maintence treatment (MMT)

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