Paliperidone-induced Polydipsia in Schizophrenia

Paliperidone使用在精神分裂症病人引起過度飲水症狀

謝依婷(Yi-Ting Hsieh) ； 洪一永(Yi-Yung Hung) ； 黃條來(Tiao-Lai Huang)

《台灣精神醫學》 27卷1期 (2013/03) Pp. 79-82

並列摘要

Objective: Polydipsia is an underdiagnosed clinical phenomenon among patients with chronic schizophrenia. Detection and management of polydipsia are clinically important because of its complications such as severe hyponatremia and water intoxication, resulting in epilepsy, coma, and death. The effect of antipsychotic drugs can cause polydipsia remains controversial. Case Report: We report a 37-year-old male patient taking paliperidone (12 mg per day) for chronic schizophrenia. After a three-week treatment with paloperidone, he developed polydipsia (daily water intake being greater than 10 liters) and hyponatremia. He did not have any other medical causes. We switched paliperidone to olanzapine (20 mg per day) due to suspected paliperidone-induced polydipsia. His daily water intake was decreased to 5 liters after two weeks, and all other associated symptoms were subsided. No relapse of polydipsia was noted in the following six months. Conclusion: Polydipsia may be related to paliperidone use. Further investigation of its cause relationship is needed.

並列關鍵字

Paliperidone ； polydipsia ； hyponatremia ； antipsychotic

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