Objective: The authors are reporting a case of hyperglycemia and hyperlipidemia after amisulpride use in treating a patient with schizophrenia and mental retardation. Case Report: A 38-year-old woman suffers from schizophrenia and mild mental retardation developed hyperglycemia and elevated serum triglyceride level after being treated with amisulpride. Conclusion: Fasting sugar and lipid profiles should be closely monitored in schizophrenia along with mental retarded patients receiving amisulpride treatment in order to facilitate early detection and intervention to prevent further metabolic complications.