The purpose of this study was to investigate the morphological characteristics of the craniofacial structures in people with open-bite malocclusion. Lateral cephalograms of untreated 80 patients with open-bite were compared with 80 people with normal occlusion. Thirty-three landmarks were traced, identified and digitized. Cephalometric analysis utilizing 23 linear, 24 angular measurements and 4 ratios were undertaken. The Student's t-test was used for statistical analysis. The results are as follows: the main differences between the open-bite combined skeletal Class Ⅰ, Ⅱ or Ⅲ exist almost in horizontal relation, but are similar in vertical relation. There is no significant difference in the angular or linear measurements of cranial base between the open-bite and the normal groups. The angular measurements of the facial pattern and the PFH/AFH ratio of the open-bite group are statistically significant compared with the normal. The average of ATFH of the open-bite group is more than the average of ATFH in the other group, most of the increased 6 amount rising from the ALFH. The mandibular plane angle, whether compared with SN, FH and PP, is significantly increased statistically, possibly resulting from the clockwise rotation of the mandible. The shorter ramal length and obtuse gonial angle are shown in the open-bite group. The vertical heights of both anterior and posterior teeth in open-bite group are increased significantly. The long axis of posterior teeth tilts toward mesially, but there is no difference in the anteriors. In this study, almost all teeth positon more anteriorly in the open-bite group.