This paper describes a nursing experience for a patient with thyrotoxic periodic paralysis. The nursing period was from September 1 to 3, 2010. Based on Gordon's eleven criteria for a functional health state, the author collected data through interview, observation, physical assessment, and chart review. Three major nursing problems were potential risk for skin integrity, anxiety, and ineffective ability of health maintenance. The author applied the nursing process through listening and communication skills. The patient and family were provided with disease-associated information, adequate clarification, and reassurance. The patient's skin integrity was maintained by means of skin care and preventative equipment. These interventions assisted the patient in going through the crisis in physiological and psychological aspects. The author hopes that this article can be shared with other nursing staffs for better understanding of disease and related care for patients with the same diagnosis.